CDKN2B

Gene Information

Official Symbol: CDKN2B
Official Name: cyclin dependent kinase inhibitor 2B
Aliases and Previous Symbols: N/A
Entrez ID: 1030
UniProt: P42772
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
UniProt Summary: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 100μM R05 exp229	-2.42
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.8
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.23

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 19067
Expression level (log2 read counts): -4.27

Expression Distribution

cyclin-dependent protein serine/threonine kinase inhibitor activity
megakaryocyte differentiation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of cellular response to transforming growth factor beta stimulus
negative regulation of cyclin-dependent protein kinase activity
cellular senescence
spleen development
cell aging
cellular response to nutrient
regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of G1/S transition of mitotic cell cycle
regulation of cyclin-dependent protein kinase activity
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of cell cycle G1/S phase transition
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
negative regulation of epithelial cell proliferation
G2/M transition of mitotic cell cycle
negative regulation of protein serine/threonine kinase activity
cell cycle G2/M phase transition
cell cycle arrest
regulation of G1/S transition of mitotic cell cycle
mitotic cell cycle checkpoint
regulation of cell cycle G1/S phase transition
cell cycle checkpoint
negative regulation of mitotic cell cycle phase transition
response to nutrient
myeloid cell differentiation
negative regulation of protein kinase activity
negative regulation of cell cycle phase transition
cellular response to nutrient levels
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of kinase activity
cellular response to extracellular stimulus
mitotic cell cycle phase transition
regulation of cellular response to growth factor stimulus
negative regulation of transferase activity
aging
cell cycle phase transition