CELF3
Gene Information
- Official Symbol: CELF3
- Official Name: CUGBP Elav-like family member 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 11189
- UniProt: Q5SZQ8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| RRM 1 |
GO Terms
| 7SK snRNA binding |
| pre-mRNA binding |
| nuclear body organization |
| positive regulation of mRNA splicing, via spliceosome |
| mRNA splice site selection |
| positive regulation of mRNA processing |
| positive regulation of RNA splicing |
| spliceosomal complex assembly |
| regulation of alternative mRNA splicing, via spliceosome |
| flagellated sperm motility |
| sperm motility |
| positive regulation of mRNA metabolic process |
| cilium-dependent cell motility |
| ncRNA transcription |
| cilium or flagellum-dependent cell motility |
| regulation of mRNA splicing, via spliceosome |
| nucleus organization |
| regulation of RNA splicing |
| regulation of mRNA processing |
| ribonucleoprotein complex |
| mRNA binding |
| ribonucleoprotein complex assembly |
| ribonucleoprotein complex subunit organization |
| nuclear body |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| regulation of mRNA metabolic process |
| RNA splicing |
| ribonucleoprotein complex biogenesis |
| mRNA processing |
| spermatogenesis |
| male gamete generation |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| gamete generation |
| mRNA metabolic process |
| multicellular organismal reproductive process |
| sexual reproduction |
| cellular protein-containing complex assembly |
| multicellular organism reproduction |
| RNA processing |
| multi-organism reproductive process |
| cell motility |
| localization of cell |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| locomotion |
| RNA binding |
| reproductive process |
| reproduction |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of gene expression |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-6727 0.001μM R01 exp42 | -1.8 |
| A-395 10μM R05 exp218 | 1.7 |
| Deguelin 0.15μM R05 exp209 | 1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13834
- Expression level (log2 read counts): -4.6
Expression Distribution
CELF3 Expression in NALM6 Cells: -4.6
