CELSR3

Entrez Summary: This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013].
UniProt Summary: Receptor that may have an important role in cell/cell signaling during nervous system formation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Latrunculin-B 10μM R07 exp374	1.91
MK2206 4μM R08 exp504	2.38

serotonergic neuron axon guidance
dopaminergic neuron axon guidance
planar cell polarity pathway involved in axon guidance
axonal fasciculation
neuron projection fasciculation
neuron recognition
Wnt signaling pathway, planar cell polarity pathway
regulation of establishment of planar polarity
neuron migration
non-canonical Wnt signaling pathway
homophilic cell adhesion via plasma membrane adhesion molecules
regulation of morphogenesis of an epithelium
cell recognition
regulation of animal organ morphogenesis
cell-cell adhesion via plasma-membrane adhesion molecules
axon guidance
neuron projection guidance
cilium assembly
cell-cell signaling by wnt
Wnt signaling pathway
cilium organization
axonogenesis
axon development
cell surface receptor signaling pathway involved in cell-cell signaling
cell morphogenesis involved in neuron differentiation
plasma membrane bounded cell projection assembly
cell projection assembly
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell-cell adhesion
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
neuron projection development
calcium ion binding
cell morphogenesis
G protein-coupled receptor activity
organelle assembly