CES2

Entrez Summary: N/A
UniProt Summary: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. {ECO:0000269|PubMed:9169443}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

COesterase
Abhydrolase 3

methylumbelliferyl-acetate deacetylase activity
methyl indole-3-acetate esterase activity
carboxylic ester hydrolase activity
prostaglandin metabolic process
prostanoid metabolic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
xenobiotic metabolic process
fatty acid derivative metabolic process
cellular response to xenobiotic stimulus
response to xenobiotic stimulus
endoplasmic reticulum lumen
fatty acid metabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxoacid metabolic process
endoplasmic reticulum
organic acid metabolic process
lipid metabolic process
extracellular space
small molecule metabolic process