CHIT1

Entrez Summary: Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Glyco hydro 18
CBM 14

endochitinase activity
chitin metabolic process
chitin catabolic process
chitinase activity
polysaccharide digestion
hydrolase activity, hydrolyzing O-glycosyl compounds
chitin binding
glucosamine-containing compound catabolic process
amino sugar catabolic process
polysaccharide catabolic process
glucosamine-containing compound metabolic process
amino sugar metabolic process
tertiary granule lumen
specific granule lumen
aminoglycan catabolic process
polysaccharide metabolic process
digestion
carbohydrate catabolic process
drug catabolic process
aminoglycan metabolic process
carbohydrate derivative catabolic process
lysosome
carbohydrate metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
drug metabolic process
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
response to bacterium
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation