CHMP3
Gene Information
- Official Symbol: CHMP3
- Official Name: charged multivesicular body protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 51652
- UniProt: Q9Y3E7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Snf7 |
GO Terms
| multivesicular body-lysosome fusion |
| endosome to lysosome transport via multivesicular body sorting pathway |
| ESCRT III complex |
| positive regulation of viral release from host cell |
| negative regulation of viral release from host cell |
| midbody abscission |
| late endosome to vacuole transport |
| ubiquitin-specific protease binding |
| regulation of early endosome to late endosome transport |
| regulation of exosomal secretion |
| viral budding via host ESCRT complex |
| mitotic cytokinetic process |
| regulation of mitotic spindle assembly |
| regulation of cytoplasmic transport |
| viral budding |
| endosome transport via multivesicular body sorting pathway |
| phosphatidylcholine binding |
| regulation of spindle assembly |
| multivesicular body assembly |
| multivesicular body organization |
| regulation of viral release from host cell |
| multivesicular body |
| autophagosome maturation |
| multivesicular body sorting pathway |
| cytokinetic process |
| virion assembly |
| regulation of mitotic spindle organization |
| regulation of centrosome duplication |
| regulation of spindle organization |
| mitotic metaphase plate congression |
| endosome to lysosome transport |
| metaphase plate congression |
| regulation of centrosome cycle |
| positive regulation of viral life cycle |
| mitotic cytokinesis |
| establishment of chromosome localization |
| chromosome localization |
| endosome organization |
| organelle membrane fusion |
| negative regulation of viral life cycle |
| protein polymerization |
| organelle fusion |
| cytoskeleton-dependent cytokinesis |
| negative regulation of viral process |
| cytokinesis |
| lysosomal transport |
| protein heterooligomerization |
| positive regulation of viral process |
| mitotic sister chromatid segregation |
| late endosome membrane |
| late endosome |
| membrane fusion |
| nucleus organization |
| sister chromatid segregation |
| vacuolar transport |
| regulation of viral life cycle |
| mitotic nuclear division |
| macroautophagy |
| regulation of mitotic nuclear division |
| regulation of microtubule cytoskeleton organization |
| regulation of nuclear division |
| viral life cycle |
| regulation of viral process |
| negative regulation of multi-organism process |
| nuclear chromosome segregation |
| regulation of organelle assembly |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of microtubule-based process |
| regulation of exocytosis |
| endosomal transport |
| protein-containing complex disassembly |
| cytoplasmic vesicle |
| autophagy |
| process utilizing autophagic mechanism |
| chromosome segregation |
| nuclear division |
| vesicle organization |
| organelle fission |
| negative regulation of locomotion |
| regulation of intracellular transport |
| establishment of organelle localization |
| cellular component disassembly |
| endomembrane system organization |
| cell division |
| positive regulation of multi-organism process |
| protein complex oligomerization |
| regulation of cytoskeleton organization |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| organelle localization |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| mitotic cell cycle |
| viral process |
| regulation of secretion by cell |
| regulation of cell cycle process |
| organelle assembly |
| regulation of multi-organism process |
| symbiotic process |
| regulation of secretion |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| membrane organization |
| protein homodimerization activity |
| regulation of cellular localization |
| apoptotic process |
| regulation of cellular component biogenesis |
| regulation of locomotion |
| cell cycle process |
| programmed cell death |
| chromosome organization |
| cell death |
| regulation of cell cycle |
| regulation of organelle organization |
| cell cycle |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| establishment of protein localization |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Dinaciclib 0.007μM R07 exp355 | -1.92 |
| DABN 20μM R00 exp17 | -1.84 |
| Hydroxyurea 100μM R07 exp329 | -1.84 |
| Aminopterin 0.005μM R07 exp335 | -1.83 |
| MLN-4924 0.2μM R00 exp21 | -1.83 |
| Genistein 15μM R07 exp360 | -1.79 |
| FK-506 30μM R07 exp359 | -1.75 |
| 5-Fluorouracil 20μM R00 exp2 | -1.71 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 175/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 7/28 |
| blood | 8/28 |
| bone | 6/26 |
| breast | 8/33 |
| central nervous system | 19/56 |
| cervix | 1/4 |
| colorectal | 1/17 |
| esophagus | 1/13 |
| fibroblast | 1/1 |
| gastric | 3/16 |
| kidney | 5/21 |
| liver | 1/20 |
| lung | 16/75 |
| lymphocyte | 7/16 |
| ovary | 4/26 |
| pancreas | 5/24 |
| peripheral nervous system | 11/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 2/24 |
| soft tissue | 4/9 |
| thyroid | 1/2 |
| upper aerodigestive | 7/22 |
| urinary tract | 8/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 2094
- Expression level (log2 read counts): 4.89
Expression Distribution
CHMP3 Expression in NALM6 Cells: 4.89
