CLCA2

Entrez Summary: N/A
UniProt Summary: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. {ECO:0000269|PubMed:10554024, ECO:0000269|PubMed:11320086, ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:15707651, ECO:0000269|PubMed:16158324}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
B02 10μM R08 exp453	-1.85
42°C R08 exp539	-1.7

ligand-gated ion channel activity
intracellular calcium activated chloride channel activity
basal plasma membrane
chloride channel activity
metallopeptidase activity
chloride transmembrane transport
chloride transport
inorganic anion transmembrane transport
inorganic anion transport
nuclear membrane
anion transmembrane transport
cell junction
anion transport
inorganic ion transmembrane transport
cell adhesion
biological adhesion
ion transmembrane transport
proteolysis
transmembrane transport
ion transport
integral component of plasma membrane
extracellular region