COPS6

Gene Information

Official Symbol: COPS6
Official Name: COP9 signalosome subunit 6
Aliases and Previous Symbols: N/A
Entrez ID: 10980
UniProt: Q7L5N1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008].
UniProt Summary: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor- responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:9535219}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LB-100 4.1μM R02 exp72	-1.84
Aminopterin 0.005μM R07 exp335	-1.76
Artemisinin 50μM R08 exp450	-1.7
NFN1 1μM R03 exp100	1.71
S-trityl-L-cysteine 0.5μM R05 exp243	1.74
HMS-I2 5μM R06 exp287	2.4
MLN-4924 0.2μM R00 exp21	2.48

Global Fraction of Cell Lines Where Essential: 734/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/26
breast	33/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 1229
Expression level (log2 read counts): 6.14

Expression Distribution

protein deneddylation
nucleotide-excision repair, DNA damage recognition
COP9 signalosome
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
protein modification by small protein removal
post-translational protein modification
DNA repair
viral process
DNA metabolic process
cellular response to DNA damage stimulus
symbiotic process
interspecies interaction between organisms
protein modification by small protein conjugation or removal
chromosome organization
proteolysis
cellular response to stress