COX5B

Gene Information

Official Symbol: COX5B
Official Name: cytochrome c oxidase subunit 5B
Aliases and Previous Symbols: N/A
Entrez ID: 1329
UniProt: P10606
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I1 10μM R06 exp256	-1.85
Calcium Ionophore 0.4μM R07 exp342	1.71
Tubacin 1.6μM R07 exp416	1.73
Trichostatin-A 0.06μM R07 exp415	1.75
GSK-J4 1.5μM R08 exp441	1.76
GSK-J4 1μM R07 exp362	1.83
5-Azacytidine 2μM R07 exp330	1.85
Selumetinib 20μM R02 exp81	2.09
SNS-032 25μM R07 exp401	2.13
Tubastatin-A 2.5μM R07 exp417	2.43

Global Fraction of Cell Lines Where Essential: 55/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	4/28
bone	3/26
breast	4/33
central nervous system	2/56
cervix	1/4
colorectal	3/17
esophagus	2/13
fibroblast	0/1
gastric	1/16
kidney	3/21
liver	0/20
lung	7/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	4/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1024
Expression level (log2 read counts): 6.36

Expression Distribution

Gene	Correlation
COX6B1	0.436
MRPS35	0.41

aerobic electron transport chain
mitochondrial electron transport, cytochrome c to oxygen
mitochondrial ATP synthesis coupled proton transport
energy coupled proton transport, down electrochemical gradient
ATP synthesis coupled proton transport
cytochrome-c oxidase activity
ATP biosynthetic process
respiratory gaseous exchange by respiratory system
purine ribonucleoside triphosphate biosynthetic process
purine nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate metabolic process
nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
aerobic respiration
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
mitochondrial transmembrane transport
nucleoside triphosphate metabolic process
respiratory electron transport chain
oxidative phosphorylation
proton transmembrane transport
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
cellular respiration
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
electron transport chain
ATP metabolic process
mitochondrial transport
energy derivation by oxidation of organic compounds
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process