CPLX1

Entrez Summary: N/A
UniProt Summary: Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. {ECO:0000250|UniProtKB:P63040, ECO:0000269|PubMed:21785414}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-2.28
Nifuroxazide 1μM R01 exp51	-1.97
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.78
D-Fructose 10000μM R06 exp279	-1.74

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
exocytic insertion of neurotransmitter receptor to postsynaptic membrane
neurotransmitter transmembrane transporter activity
regulation of synaptic vesicle fusion to presynaptic active zone membrane
neurotransmitter receptor transport to plasma membrane
neurotransmitter receptor transport to postsynaptic membrane
establishment of protein localization to postsynaptic membrane
calyx of Held
syntaxin-1 binding
glutamate secretion
regulation of vesicle fusion
neurotransmitter receptor transport
protein localization to postsynaptic membrane
insulin secretion
receptor localization to synapse
acidic amino acid transport
regulation of postsynaptic membrane neurotransmitter receptor levels
SNARE complex
terminal bouton
peptide hormone secretion
protein localization to synapse
synaptic vesicle exocytosis
SNARE binding
hormone secretion
regulation of synaptic vesicle exocytosis
dicarboxylic acid transport
acid secretion
hormone transport
Schaffer collateral - CA1 synapse
postsynapse
vesicle-mediated transport to the plasma membrane
neurotransmitter secretion
signal release from synapse
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
amino acid transport
synaptic vesicle cycle
vesicle-mediated transport in synapse
regulation of neurotransmitter transport