CPNE1

Entrez Summary: N/A
UniProt Summary: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha- induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740). {ECO:0000269|PubMed:12522145, ECO:0000269|PubMed:14674885, ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:19539605, ECO:0000269|PubMed:23263657, ECO:0000269|PubMed:25450385, ECO:0000269|PubMed:9430674}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Isoniazid 100μM R08 exp494	-2.31
UM131593 0.2μM R03 exp106	-1.85
ABT-702 0.1μM R06 exp260	-1.73
Sucrose 20000μM R06 exp298	-1.71
NN-Dimethylsphingosine 2.5μM R08 exp508	1.74
Golgicide-A 4μM R03 exp122	1.76
ZLN024 50μM R08 exp538	1.81

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

C2
Copine

positive regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of NIK/NF-kappaB signaling
NF-kappaB binding
transporter activity
positive regulation of cytokine-mediated signaling pathway
negative regulation of DNA binding
calcium-dependent phospholipid binding
positive regulation of response to cytokine stimulus
regulation of tumor necrosis factor-mediated signaling pathway
azurophil granule membrane
phosphatidylserine binding
neuron projection extension
endopeptidase activity
cellular response to calcium ion
developmental cell growth
cell growth
regulation of NIK/NF-kappaB signaling
developmental growth involved in morphogenesis
regulation of DNA binding
response to calcium ion
regulation of cytokine-mediated signaling pathway
positive regulation of protein kinase B signaling
negative regulation of binding
regulation of response to cytokine stimulus
cellular response to metal ion
glycerophospholipid biosynthetic process
cellular response to inorganic substance
regulation of protein kinase B signaling
glycerolipid biosynthetic process
regulation of I-kappaB kinase/NF-kappaB signaling
nuclear membrane
phospholipid biosynthetic process
glycerophospholipid metabolic process
positive regulation of neuron differentiation
response to metal ion
phospholipid metabolic process
regulation of binding
glycerolipid metabolic process
developmental growth
growth