CSAD

Entrez Summary: This gene encodes a member of the group 2 decarboxylase family. A similar protein in rodents plays a role in multiple biological processes as the rate-limiting enzyme in taurine biosynthesis, catalyzing the decarboxylation of cysteinesulfinate to hypotaurine. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution

L-cysteine catabolic process to hypotaurine
L-cysteine catabolic process to taurine
alkanesulfonate biosynthetic process
aspartate 1-decarboxylase activity
taurine biosynthetic process
sulfinoalanine decarboxylase activity
L-cysteine metabolic process
L-cysteine catabolic process
cysteine catabolic process
taurine metabolic process
alkanesulfonate metabolic process
cysteine metabolic process
sulfur amino acid catabolic process
serine family amino acid catabolic process
sulfur amino acid metabolic process
serine family amino acid metabolic process
pyridoxal phosphate binding
sulfur compound catabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
xenobiotic metabolic process
sulfur compound biosynthetic process
cellular response to xenobiotic stimulus
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
response to xenobiotic stimulus
organic acid biosynthetic process
cellular amino acid metabolic process
sulfur compound metabolic process
small molecule catabolic process
small molecule biosynthetic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
organonitrogen compound biosynthetic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process