CST4

Entrez Summary: N/A
UniProt Summary: This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Ethanol 0.01 R05 exp234	-1.82
D-Fructose 10000μM R06 exp279	1.97

cysteine-type endopeptidase inhibitor activity
detection of chemical stimulus involved in sensory perception of bitter taste
sensory perception of bitter taste
detection of chemical stimulus involved in sensory perception of taste
sensory perception of taste
retina homeostasis
tissue homeostasis
negative regulation of endopeptidase activity
negative regulation of peptidase activity
multicellular organismal homeostasis
anatomical structure homeostasis
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
detection of chemical stimulus involved in sensory perception
detection of chemical stimulus
sensory perception of chemical stimulus
detection of stimulus involved in sensory perception
detection of stimulus
regulation of proteolysis
negative regulation of catalytic activity
sensory perception
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
nervous system process
extracellular space
homeostatic process
system process