CTF1

Gene Information

Official Symbol: CTF1
Official Name: cardiotrophin 1
Aliases and Previous Symbols: N/A
Entrez ID: 1489
UniProt: Q16619
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
UniProt Summary: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8564
Expression level (log2 read counts): 0.62

Expression Distribution

Screen	Score
FTY720 3μM R08 exp483	1.76
Rapamycin 10μM R00 exp30	1.94
Rifampicin 10μM R00 exp32	2.34

leukemia inhibitory factor receptor binding
leukemia inhibitory factor signaling pathway
positive regulation of tyrosine phosphorylation of STAT protein
regulation of tyrosine phosphorylation of STAT protein
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via STAT
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
cytokine activity
positive regulation of peptidyl-tyrosine phosphorylation
regulation of peptidyl-tyrosine phosphorylation
muscle organ development
muscle structure development
cytokine-mediated signaling pathway
enzyme linked receptor protein signaling pathway
neuron development
positive regulation of cell population proliferation
cellular response to cytokine stimulus
neuron differentiation
positive regulation of protein phosphorylation
positive regulation of phosphorylation
response to cytokine
cell-cell signaling
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
regulation of protein phosphorylation
generation of neurons
regulation of phosphorylation
extracellular space
positive regulation of cellular protein metabolic process
regulation of cell population proliferation
neurogenesis
cell development
positive regulation of signal transduction
positive regulation of protein metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of cell communication
positive regulation of signaling