CWC27

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-3.07
Staurosporine 0.02μM R08 exp524	-2.51
UMK57 0.6μM R03 exp107	-2.32
Pimelic-diphenylamide-106 5μM R00 exp28	-2.25
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.17
GSK2606414 1μM R05 exp236	-1.94
Sulforaphane 9μM R08 exp526 no dilution day6	-1.78
MS023 2μM R03 exp134	-1.75
Quercetin 20μM R08 exp517	-1.72
BI-D1870 2μM R04 exp162	1.76
Rapamycin 0.001μM R08 exp429	1.97
Rapamycin 2μM R07 exp306	2.33

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cyclosporin A binding
peptidyl-prolyl cis-trans isomerase activity
protein peptidyl-prolyl isomerization
U2-type precatalytic spliceosome
peptidyl-proline modification
catalytic step 2 spliceosome
protein folding
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
mRNA metabolic process
RNA processing
peptidyl-amino acid modification
RNA metabolic process
gene expression