DCST1

Gene Information

Official Symbol: DCST1
Official Name: DC-STAMP domain containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 149095
UniProt: Q5T197
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
UniProt Summary: E3 ubiquitin-protein ligase which mediates 'Lys-48'- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. {ECO:0000269|PubMed:27782195}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6457
Expression level (log2 read counts): -0.93

Expression Distribution

negative regulation of type I interferon-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
negative regulation of innate immune response
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
negative regulation of response to biotic stimulus
negative regulation of immune response
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
negative regulation of defense response
negative regulation of multi-organism process
ubiquitin protein ligase activity
negative regulation of response to external stimulus
negative regulation of immune system process
regulation of innate immune response
regulation of response to biotic stimulus
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
regulation of defense response
innate immune response
protein modification by small protein conjugation
regulation of multi-organism process
cellular macromolecule catabolic process
defense response to other organism
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
regulation of response to external stimulus
regulation of immune response
negative regulation of signal transduction
proteolysis
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response