DDX51

Entrez Summary: N/A
UniProt Summary: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 295/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	6/28
blood	7/28
bone	10/26
breast	16/33
central nervous system	37/56
cervix	2/4
colorectal	6/17
esophagus	5/13
fibroblast	1/1
gastric	3/16
kidney	13/21
liver	8/20
lung	22/75
lymphocyte	7/16
ovary	6/26
pancreas	6/24
peripheral nervous system	3/16
plasma cell	6/15
prostate	0/1
skin	11/24
soft tissue	3/9
thyroid	1/2
upper aerodigestive	12/22
urinary tract	8/29
uterus	1/5

Expression Distribution

Screen	Score
PU-H71 1μM R08 exp515	-1.9
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2

RNA helicase activity
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
ATP binding
RNA metabolic process
membrane
gene expression