DENND1A

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Dimethyloxaloylglycine 100μM R05 exp229	-1.81
S-trityl-L-cysteine 0.5μM R05 exp243	-1.75

regulation of Rab protein signal transduction
phosphatidylinositol phosphate binding
endocytic recycling
Rab guanyl-nucleotide exchange factor activity
phosphatidylinositol-3-phosphate binding
synaptic vesicle endocytosis
presynaptic endocytosis
synaptic vesicle recycling
clathrin-coated vesicle membrane
clathrin-coated vesicle
presynaptic membrane
synaptic vesicle cycle
vesicle-mediated transport in synapse
SH3 domain binding
Rab GTPase binding
endosomal transport
regulation of Ras protein signal transduction
regulation of small GTPase mediated signal transduction
neuronal cell body
positive regulation of GTPase activity
dendrite
regulation of GTPase activity
cell junction
endocytosis
import into cell
intracellular membrane-bounded organelle
positive regulation of hydrolase activity
regulation of hydrolase activity
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
establishment of protein localization
positive regulation of molecular function
regulation of intracellular signal transduction
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport