DMC1

Entrez Summary: This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
UniProt Summary: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

recombinase activity
strand invasion
DNA recombinase assembly
DNA repair complex assembly
double-strand break repair via synthesis-dependent strand annealing
mitotic recombination
oocyte maturation
male meiosis I
condensed nuclear chromosome
oocyte development
oocyte differentiation
DNA-dependent ATPase activity
synapsis
male meiotic nuclear division
chromosome, telomeric region
ovarian follicle development
reciprocal meiotic recombination
homologous recombination
homologous chromosome segregation
chromosome organization involved in meiotic cell cycle
oogenesis
female gonad development
meiotic chromosome segregation
development of primary female sexual characteristics
double-strand break repair via homologous recombination
recombinational repair
double-stranded DNA binding
female sex differentiation
single-stranded DNA binding
meiosis I
meiosis I cell cycle process
chromosome
female gamete generation
anatomical structure maturation
spermatid development
meiotic nuclear division
spermatid differentiation
cell maturation
meiotic cell cycle process
double-strand break repair