DNAI1
Gene Information
- Official Symbol: DNAI1
- Official Name: dynein axonemal intermediate chain 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 27019
- UniProt: Q9UI46
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
- UniProt Summary: Part of the dynein complex of respiratory cilia.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3575
- Expression level (log2 read counts): -3.59
DNAI1 Expression in NALM6 Cells: -3.59
