DOCK5

Gene Information

Official Symbol: DOCK5
Official Name: dedicator of cytokinesis 5
Aliases and Previous Symbols: N/A
Entrez ID: 80005
UniProt: Q9H7D0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016].
UniProt Summary: Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	3/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7519
Expression level (log2 read counts): 3.27

Expression Distribution

Screen	Score
Etoposide 0.1μM R05 exp198	-1.85
Epothilone-B 0.0015μM R05 exp231	-1.72
Apcin 50 to 100μM on day4 R04 exp176	-1.71
NFN1 0.4μM R03 exp99	-1.7

SH3 2
Ded cyto
SH3 1

negative regulation of vascular smooth muscle contraction
negative regulation of vasoconstriction
regulation of vascular smooth muscle contraction
negative regulation of smooth muscle contraction
positive regulation of vascular associated smooth muscle cell migration
regulation of vascular associated smooth muscle cell migration
negative regulation of muscle contraction
negative regulation of blood circulation
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of smooth muscle cell migration
regulation of substrate adhesion-dependent cell spreading
positive regulation of blood vessel diameter
regulation of vasoconstriction
regulation of smooth muscle contraction
regulation of smooth muscle cell migration
guanyl-nucleotide exchange factor activity
positive regulation of cell-substrate adhesion
regulation of blood vessel diameter
regulation of tube diameter
regulation of tube size
positive regulation of epithelial cell migration
positive regulation of cell morphogenesis involved in differentiation
regulation of muscle contraction
vascular process in circulatory system
regulation of cell-substrate adhesion
regulation of epithelial cell migration
regulation of muscle system process
GTPase activator activity
regulation of blood circulation
regulation of cell morphogenesis involved in differentiation
small GTPase mediated signal transduction
blood circulation
circulatory system process
positive regulation of cell adhesion
positive regulation of GTPase activity
regulation of GTPase activity
regulation of cell morphogenesis
positive regulation of cell migration
regulation of anatomical structure size
positive regulation of cell motility