DRD5
Gene Information
- Official Symbol: DRD5
- Official Name: dopamine receptor D5
- Aliases and Previous Symbols: N/A
- Entrez ID: 1816
- UniProt: P21918
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008].
- UniProt Summary: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. {ECO:0000269|PubMed:1834671}.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
| 7TM GPCR Srsx |
GO Terms
| dopamine neurotransmitter receptor activity, coupled via Gs |
| sensitization |
| negative regulation of NAD(P)H oxidase activity |
| norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure |
| dopamine neurotransmitter receptor activity |
| regulation of systemic arterial blood pressure by vasopressin |
| positive regulation of blood pressure by epinephrine-norepinephrine |
| nonassociative learning |
| phospholipase C-activating dopamine receptor signaling pathway |
| regulation of female receptivity |
| regulation of systemic arterial blood pressure by norepinephrine-epinephrine |
| positive regulation of adenylate cyclase activity |
| female mating behavior |
| adenylate cyclase-activating dopamine receptor signaling pathway |
| regulation of NAD(P)H oxidase activity |
| dopamine binding |
| long-term synaptic depression |
| synaptic transmission, dopaminergic |
| mating behavior |
| positive regulation of cyclase activity |
| positive regulation of lyase activity |
| negative regulation of oxidoreductase activity |
| G-protein alpha-subunit binding |
| regulation of adenylate cyclase activity |
| reproductive behavior |
| vasoconstriction |
| non-motile cilium |
| response to amphetamine |
| mating |
| dopamine receptor signaling pathway |
| regulation of systemic arterial blood pressure by hormone |
| positive regulation of blood pressure |
| activation of adenylate cyclase activity |
| negative regulation of blood vessel diameter |
| regulation of cyclase activity |
| regulation of lyase activity |
| negative regulation of blood pressure |
| regulation of systemic arterial blood pressure mediated by a chemical signal |
| response to amine |
| endocrine process |
| response to bronchodilator |
| brush border membrane |
| ciliary membrane |
| transmission of nerve impulse |
| response to cocaine |
| negative regulation of synaptic transmission |
| associative learning |
| response to anesthetic |
| cellular response to dopamine |
| response to dopamine |
| signal transduction involved in cellular response to ammonium ion |
| regulation of systemic arterial blood pressure |
| regulation of oxidoreductase activity |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| cellular response to monoamine stimulus |
| cellular response to catecholamine stimulus |
| response to monoamine |
| response to catecholamine |
| response to alkaloid |
| reactive oxygen species metabolic process |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| cellular response to ammonium ion |
| multicellular organismal signaling |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| regulation of tube size |
| learning |
| cAMP-mediated signaling |
| vascular process in circulatory system |
| cyclic-nucleotide-mediated signaling |
| regulation of blood pressure |
| response to ammonium ion |
| regulation of synaptic plasticity |
| cilium |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| learning or memory |
| cognition |
| response to xenobiotic stimulus |
| second-messenger-mediated signaling |
| blood circulation |
| circulatory system process |
| cellular response to drug |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| wound healing |
| divalent inorganic cation homeostasis |
| response to toxic substance |
| regulation of anatomical structure size |
| cellular response to organic cyclic compound |
| cellular metal ion homeostasis |
| response to wounding |
| behavior |
| cellular response to organonitrogen compound |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cellular response to nitrogen compound |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| negative regulation of catalytic activity |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| cellular homeostasis |
| response to organic cyclic compound |
| multi-organism reproductive process |
| response to organonitrogen compound |
| response to drug |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| chemical homeostasis |
| cell-cell signaling |
| negative regulation of molecular function |
| cellular response to endogenous stimulus |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| nervous system process |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| homeostatic process |
| intracellular signal transduction |
| positive regulation of molecular function |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| RO-3306 3 to 4μM on day4 R04 exp165 | -1.91 |
| SGC0649 7μM R03 exp150 | -1.86 |
| Nifurtimox 1μM R03 exp141 | -1.74 |
| MKC9989 10μM R03 exp133 | -1.71 |
| THZ531 0.225μM R08 exp444 | 2.02 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4202
- Expression level (log2 read counts): -7.68
Expression Distribution
DRD5 Expression in NALM6 Cells: -7.68
