DUOX2

Entrez Summary: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008].
UniProt Summary: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269|PubMed:12824283}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rifampicin 1μM R00 exp31	-1.99
BI-D1870 3.15μM R02 exp66	-1.94
Rapamycin 1μM R00 exp29	-1.88
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.87
Cyclosporin-A 3μM R07 exp348	-1.82
IU1-C 25μM R04 exp183	-1.81
3-Bromopyruvate 7μM R04 exp175	1.77
CR131-b 0.005μM R08 exp474	2.09

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cuticle development
NAD(P)H oxidase activity
hydrogen peroxide biosynthetic process
superoxide-generating NADPH oxidase activity
thyroid hormone generation
antibiotic biosynthetic process
NADPH oxidase complex
superoxide anion generation
thyroid hormone metabolic process
reactive oxygen species biosynthetic process
hydrogen peroxide catabolic process
peroxidase activity
hydrogen peroxide metabolic process
superoxide metabolic process
cell leading edge
antibiotic catabolic process
positive regulation of wound healing
cofactor catabolic process
hormone biosynthetic process
positive regulation of response to wounding
apical part of cell
phenol-containing compound metabolic process
cellular oxidant detoxification
response to cAMP
cellular detoxification
antibiotic metabolic process
reactive oxygen species metabolic process
detoxification
response to organophosphorus
regulation of wound healing
heme binding
drug catabolic process
response to purine-containing compound
regulation of response to wounding
cellular modified amino acid metabolic process
hormone metabolic process
cofactor biosynthetic process
cellular response to toxic substance
response to virus
apical plasma membrane