ECHS1
Gene Information
- Official Symbol: ECHS1
- Official Name: enoyl-CoA hydratase, short chain 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1892
- UniProt: P30084
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. [provided by RefSeq, Jul 2008].
- UniProt Summary: Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate. {ECO:0000269|PubMed:26251176}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8927
- Expression level (log2 read counts): 5.8
ECHS1 Expression in NALM6 Cells: 5.8
