ELP4

Entrez Summary: This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
UniProt Summary: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. {ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576, ECO:0000269|PubMed:16713582}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MS023 7μM R03 exp135	1.76
Lead acetate 2000μM R08 exp498 no dilution day6	1.86
MLN-4924 0.2μM R00 exp21	2.09
Hippuristanol 0.12μM R08 exp488	2.57
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.72

Global Fraction of Cell Lines Where Essential: 4/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

phosphorylase kinase regulator activity
Elongator holoenzyme complex
tRNA wobble uridine modification
tRNA wobble base modification
transcription elongation factor complex
RNA polymerase II complex binding
transcription elongation from RNA polymerase II promoter
tRNA modification
DNA-templated transcription, elongation
tRNA processing
RNA modification
tRNA metabolic process
ncRNA processing
ncRNA metabolic process
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of protein kinase activity
regulation of kinase activity
RNA processing
regulation of transferase activity
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
regulation of protein phosphorylation
regulation of phosphorylation
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
gene expression