EMC10

Gene Information

Official Symbol: EMC10
Official Name: ER membrane protein complex subunit 10
Aliases and Previous Symbols: N/A
Entrez ID: 284361
UniProt: Q5UCC4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12770
Expression level (log2 read counts): 6.89

Expression Distribution

Screen	Score
VER-155008 3.9μM R06 exp301	-2.07
ABT-702 5μM R06 exp261	-1.88
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.73
ETC-159 50μM R08 exp480	1.79

ER membrane protein complex
positive regulation of p38MAPK cascade
regulation of p38MAPK cascade
positive regulation of endothelial cell proliferation
positive regulation of endothelial cell migration
regulation of endothelial cell proliferation
positive regulation of epithelial cell migration
regulation of endothelial cell migration
positive regulation of angiogenesis
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
positive regulation of vasculature development
positive regulation of epithelial cell proliferation
regulation of epithelial cell migration
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
regulation of angiogenesis
angiogenesis
regulation of vasculature development
regulation of epithelial cell proliferation
blood vessel morphogenesis
blood vessel development
positive regulation of cell migration
vasculature development
cardiovascular system development
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of MAPK cascade
positive regulation of locomotion
tube morphogenesis
regulation of cellular response to stress
regulation of MAPK cascade
tube development
regulation of cell migration
circulatory system development
anatomical structure formation involved in morphogenesis
regulation of cell motility
positive regulation of cell population proliferation
regulation of locomotion
regulation of cellular component movement