EPAS1

Entrez Summary: This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009].
UniProt Summary: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Asunaprenir 3μM R07 exp336	-2.46
OICR-9429 10μM R03 exp142	-2.39
Aminopterin 0.005μM R07 exp335	-2.2
Staurosporine 0.02μM R08 exp524	-2.05
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.83
Senexin-A 25μM R07 exp400	-1.78
Alpha-Amanitin 0.5μM R00 exp5	1.74
Losmapimod 1μM R07 exp376	1.81
CCCP 1μM R00 exp11	1.84
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.87

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

myoblast fate commitment
surfactant homeostasis
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
norepinephrine metabolic process
chemical homeostasis within a tissue
histone acetyltransferase binding
blood vessel remodeling
myoblast differentiation
catecholamine metabolic process
catechol-containing compound metabolic process
regulation of transcription from RNA polymerase II promoter in response to hypoxia
erythrocyte differentiation
iron ion homeostasis
phenol-containing compound metabolic process
embryonic placenta development
erythrocyte homeostasis
regulation of heart rate
positive regulation of cold-induced thermogenesis
tissue remodeling
myeloid cell homeostasis
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
transition metal ion homeostasis
regulation of cold-induced thermogenesis
placenta development
cell maturation
lung development
respiratory tube development
cellular response to hypoxia
tissue homeostasis
respiratory system development
cellular response to decreased oxygen levels
homeostasis of number of cells
transcription factor complex
cellular response to oxygen levels
myeloid cell differentiation
visual perception
sensory perception of light stimulus
cellular response to oxidative stress
developmental maturation