EPG5

Entrez Summary: This gene encodes a large coiled coil domain-containing protein that functions in autophagy during starvation conditions. Mutations in this gene cause Vici syndrome. [provided by RefSeq, Aug 2015].
UniProt Summary: Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. {ECO:0000269|PubMed:20550938, ECO:0000269|PubMed:23222957}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

response to dsDNA
cellular response to dsDNA
toll-like receptor 9 signaling pathway
nucleotide transport
autophagosome maturation
endocytic recycling
endosome to lysosome transport
toll-like receptor signaling pathway
lysosomal transport
organophosphate ester transport
pattern recognition receptor signaling pathway
vacuolar transport
macroautophagy
endosomal transport
innate immune response-activating signal transduction
protein-containing complex disassembly
nucleobase-containing compound transport
lysosome
activation of innate immune response
autophagy
process utilizing autophagic mechanism
positive regulation of innate immune response
positive regulation of response to biotic stimulus
cellular component disassembly
regulation of innate immune response
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
cellular response to organic cyclic compound
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
activation of immune response
cellular response to nitrogen compound
perinuclear region of cytoplasm
regulation of defense response
regulation of multi-organism process
positive regulation of immune response
response to organic cyclic compound
response to nitrogen compound