EPPIN

Entrez Summary: N/A
UniProt Summary: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. {ECO:0000269|PubMed:15229136, ECO:0000269|PubMed:17644992}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

WAP
Kunitz BPTI

negative regulation of cilium-dependent cell motility
sperm plasma membrane
negative regulation of flagellated sperm motility
negative regulation of calcium ion import
regulation of flagellated sperm motility
regulation of cilium-dependent cell motility
regulation of calcium ion import
negative regulation of reproductive process
negative regulation of calcium ion transport
serine-type endopeptidase inhibitor activity
antimicrobial humoral response
negative regulation of ion transport
regulation of reproductive process
negative regulation of endopeptidase activity
regulation of calcium ion transport
negative regulation of peptidase activity
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
defense response to bacterium
humoral immune response
negative regulation of proteolysis
regulation of metal ion transport
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
negative regulation of transport
protein complex oligomerization
protein-containing complex
cell surface
response to bacterium
regulation of ion transport
regulation of proteolysis
negative regulation of catalytic activity
regulation of cell motility
defense response to other organism
regulation of locomotion
regulation of cellular component movement
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process