EXOG

Entrez Summary: N/A
UniProt Summary: Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity. {ECO:0000269|PubMed:18187503}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

exodeoxyribonuclease activity
single-stranded DNA endodeoxyribonuclease activity
5-3 exonuclease activity
apoptotic DNA fragmentation
DNA catabolic process, endonucleolytic
apoptotic nuclear changes
cellular component disassembly involved in execution phase of apoptosis
endoribonuclease activity
DNA catabolic process
endonuclease activity
execution phase of apoptosis
RNA phosphodiester bond hydrolysis, endonucleolytic
RNA phosphodiester bond hydrolysis
nucleic acid binding
nucleic acid phosphodiester bond hydrolysis
nucleobase-containing compound catabolic process
mitochondrial inner membrane
cellular component disassembly
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
protein-containing complex
DNA metabolic process
cellular macromolecule catabolic process
apoptotic process
macromolecule catabolic process
programmed cell death
cell death
mitochondrion
RNA metabolic process
organic substance catabolic process
cellular catabolic process