EXT1

Entrez Summary: This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses. [provided by RefSeq, Jul 2008].
UniProt Summary: Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:11518722, ECO:0000269|PubMed:22660413}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Exostosin
Glyco transf 64

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
heparan sulfate N-acetylglucosaminyltransferase activity
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
embryonic skeletal joint development
transferase activity, transferring glycosyl groups
acetylglucosaminyltransferase activity
glucuronosyltransferase activity
heparan sulfate proteoglycan biosynthetic process
olfactory bulb development
olfactory lobe development
heparan sulfate proteoglycan metabolic process
cellular polysaccharide biosynthetic process
polysaccharide biosynthetic process
cellular carbohydrate biosynthetic process
proteoglycan biosynthetic process
endoderm development
cellular polysaccharide metabolic process
polysaccharide metabolic process
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
integral component of endoplasmic reticulum membrane
aminoglycan biosynthetic process
mesoderm development
carbohydrate biosynthetic process
embryonic skeletal system development
glycosaminoglycan metabolic process
gastrulation
aminoglycan metabolic process
cellular carbohydrate metabolic process
macromolecule glycosylation
telencephalon development
protein glycosylation
axon guidance
neuron projection guidance
ossification
glycosylation
glycoprotein biosynthetic process
axonogenesis
glycoprotein metabolic process