FAIM2

Entrez Summary: N/A
UniProt Summary: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. {ECO:0000269|PubMed:10535980, ECO:0000269|PubMed:17635665}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyl-Sulfoxide 1pc R03 exp120	-1.93
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.78
Epothilone-B 0.0015μM R05 exp231	-1.71
PT-1 25μM R07 exp392	1.9
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.97

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cerebellar Purkinje cell differentiation
cerebellar Purkinje cell layer formation
cerebellar granular layer development
cerebellar Purkinje cell layer morphogenesis
cell differentiation in hindbrain
cerebellar cortex formation
cerebellar Purkinje cell layer development
cerebellar cortex morphogenesis
cerebellum morphogenesis
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
hindbrain morphogenesis
cerebellar cortex development
response to ischemia
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway
cerebellum development
metencephalon development
negative regulation of neuron apoptotic process
hindbrain development
regulation of extrinsic apoptotic signaling pathway
central nervous system neuron differentiation
postsynaptic membrane
regulation of neuron apoptotic process
negative regulation of neuron death
membrane raft
negative regulation of apoptotic signaling pathway
regulation of neuron death
regulation of apoptotic signaling pathway
cell junction
brain development
head development
negative regulation of apoptotic process
anatomical structure formation involved in morphogenesis
negative regulation of programmed cell death
apoptotic process
central nervous system development
Golgi apparatus
negative regulation of cell death
neuron differentiation
endoplasmic reticulum