FAM208A

Entrez Summary: N/A
UniProt Summary: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. {ECO:0000269|PubMed:26022416}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
MORC2	0.49
MPHOSPH8	0.48

protein localization to heterochromatin
positive regulation of methylation-dependent chromatin silencing
regulation of methylation-dependent chromatin silencing
positive regulation of chromatin silencing
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
regulation of single stranded viral RNA replication via double stranded DNA intermediate
protein localization to chromatin
heterochromatin
regulation of chromatin silencing
negative regulation of viral genome replication
protein localization to chromosome
negative regulation of viral life cycle
negative regulation of gene expression, epigenetic
regulation of viral genome replication
negative regulation of viral process
positive regulation of chromatin organization
regulation of gene silencing
regulation of viral life cycle
positive regulation of chromosome organization
regulation of chromatin organization
regulation of viral process
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
regulation of gene expression, epigenetic
regulation of chromosome organization
chromatin binding
positive regulation of organelle organization
protein localization to organelle
regulation of multi-organism process
positive regulation of cellular component organization
regulation of organelle organization
RNA binding
cellular protein localization
cellular macromolecule localization
negative regulation of gene expression