FCAR

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CCCP 0.1μM R00 exp10	-1.94
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.76
2-Methoxyestradiol 0.2μM R01 exp40	-1.7
BI-6727 0.0125μM R03 exp97	1.74
Senexin-A 25μM R07 exp400	1.76
CI-1040 9.5μM R08 exp472	1.78

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

IgA binding
ficolin-1-rich granule membrane
tertiary granule membrane
specific granule membrane
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation
secretion by cell
export from cell
cell activation
immune effector process
secretion
integral component of plasma membrane
immune response
extracellular region
vesicle-mediated transport