FLRT2

Entrez Summary: N/A
UniProt Summary: Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. {ECO:0000250|UniProtKB:Q8BLU0}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell adhesion involved in heart morphogenesis
fibroblast growth factor receptor binding
basement membrane organization
chemorepellent activity
regulation of neuron migration
negative chemotaxis
positive regulation of synapse assembly
protein binding, bridging
fibroblast growth factor receptor signaling pathway
regulation of synapse assembly
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
cell-cell junction
regulation of synapse organization
regulation of synapse structure or activity
extracellular matrix
heart morphogenesis
axon guidance
neuron projection guidance
synapse
neuron projection
extracellular matrix organization
axonogenesis
extracellular structure organization
axon development
focal adhesion
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis
positive regulation of cellular component biogenesis
heart development
response to growth factor
positive regulation of nervous system development
chemotaxis
taxis
cell morphogenesis involved in differentiation