GADD45A
Gene Information
- Official Symbol: GADD45A
- Official Name: growth arrest and DNA damage inducible alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 1647
- UniProt: P24522
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L7Ae |
GO Terms
| activation of MAPKKK activity |
| mitotic cell cycle arrest |
| positive regulation of p38MAPK cascade |
| RNA polymerase II core promoter sequence-specific DNA binding |
| regulation of p38MAPK cascade |
| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| signal transduction involved in mitotic DNA damage checkpoint |
| signal transduction involved in mitotic cell cycle checkpoint |
| signal transduction involved in mitotic G1 DNA damage checkpoint |
| intracellular signal transduction involved in G1 DNA damage checkpoint |
| signal transduction involved in mitotic DNA integrity checkpoint |
| mitotic G1 DNA damage checkpoint |
| mitotic G1/S transition checkpoint |
| G1 DNA damage checkpoint |
| cellular response to ionizing radiation |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in cell cycle checkpoint |
| DNA damage response, signal transduction by p53 class mediator |
| cellular response to mechanical stimulus |
| positive regulation of cell cycle arrest |
| centrosome cycle |
| microtubule organizing center organization |
| kinase binding |
| mitotic DNA damage checkpoint |
| positive regulation of reactive oxygen species metabolic process |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of cyclin-dependent protein kinase activity |
| negative regulation of G1/S transition of mitotic cell cycle |
| mitotic DNA integrity checkpoint |
| signal transduction in response to DNA damage |
| negative regulation of cell cycle G1/S phase transition |
| protein N-terminus binding |
| regulation of cell cycle arrest |
| signal transduction by p53 class mediator |
| DNA damage checkpoint |
| positive regulation of JNK cascade |
| DNA integrity checkpoint |
| cell cycle arrest |
| response to ionizing radiation |
| regulation of G1/S transition of mitotic cell cycle |
| mitotic cell cycle checkpoint |
| regulation of cell cycle G1/S phase transition |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| cellular response to radiation |
| regulation of reactive oxygen species metabolic process |
| regulation of JNK cascade |
| cell cycle checkpoint |
| negative regulation of mitotic cell cycle phase transition |
| response to mechanical stimulus |
| negative regulation of protein kinase activity |
| negative regulation of cell cycle phase transition |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| negative regulation of kinase activity |
| positive regulation of MAP kinase activity |
| negative regulation of transferase activity |
| positive regulation of cell cycle process |
| negative regulation of mitotic cell cycle |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| negative regulation of cell cycle process |
| activation of protein kinase activity |
| cellular response to external stimulus |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| positive regulation of cell cycle |
| nuclear speck |
| negative regulation of protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| response to radiation |
| negative regulation of phosphorylation |
| regulation of cell cycle phase transition |
| microtubule cytoskeleton organization |
| protein heterodimerization activity |
| DNA repair |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| negative regulation of protein modification process |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of transferase activity |
| microtubule-based process |
| mitotic cell cycle |
| positive regulation of cell death |
| regulation of cellular response to stress |
| DNA metabolic process |
| regulation of MAPK cascade |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of kinase activity |
| protein homodimerization activity |
| apoptotic process |
| regulation of transferase activity |
| cell cycle process |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| positive regulation of phosphorylation |
| cell death |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| regulation of cell cycle |
| positive regulation of protein modification process |
| cell cycle |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Hypoxia 5%O2 R04 exp191 | -2.08 |
| Rapamycin 10μM R00 exp30 | -1.9 |
| Rapamycin 1μM R00 exp29 | -1.87 |
| BI-6727 0.001μM R01 exp42 | -1.8 |
| Wortmannin 5μM R00 exp38 | -1.77 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15379
- Expression level (log2 read counts): 4.31
Expression Distribution
GADD45A Expression in NALM6 Cells: 4.31
