GALC

Entrez Summary: This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
UniProt Summary: Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon. {ECO:0000269|PubMed:8281145, ECO:0000269|PubMed:8399327}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

galactosylceramidase activity
galactosylceramide catabolic process
galactolipid catabolic process
glycosylceramide catabolic process
galactosylceramide metabolic process
galactolipid metabolic process
glycosphingolipid catabolic process
glycolipid catabolic process
glycosylceramide metabolic process
ceramide catabolic process
sphingolipid catabolic process
membrane lipid catabolic process
glycosphingolipid metabolic process
ceramide metabolic process
lysosomal lumen
myelination
ensheathment of neurons
axon ensheathment
glycolipid metabolic process
liposaccharide metabolic process
sphingolipid metabolic process
carbohydrate derivative catabolic process
cellular lipid catabolic process
membrane lipid metabolic process
lysosome
lipid catabolic process
cellular amide metabolic process
cellular lipid metabolic process
carbohydrate derivative metabolic process
organonitrogen compound catabolic process
lipid metabolic process
organic substance catabolic process
cellular catabolic process