GBAS

Gene Information

Official Symbol: NIPSNAP2
Official Name: nipsnap homolog 2
Aliases and Previous Symbols: N/A
Entrez ID: 2631
UniProt: O75323
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May act as a positive regulator of L-type calcium channels. {ECO:0000250|UniProtKB:O55126}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14033
Expression level (log2 read counts): 5.18

Expression Distribution

Screen	Score
Phenformin 20μM R03 exp143	-1.81
Nocodazole 0.1μM R03 exp94	1.71
Rotenone 2μM R00 exp33	1.91
Nocodazole 0.2μM R00 exp24	1.98

positive regulation of high voltage-gated calcium channel activity
positive regulation of voltage-gated calcium channel activity
regulation of high voltage-gated calcium channel activity
regulation of voltage-gated calcium channel activity
positive regulation of calcium ion transmembrane transporter activity
positive regulation of cation channel activity
positive regulation of calcium ion transmembrane transport
regulation of calcium ion transmembrane transporter activity
positive regulation of ion transmembrane transporter activity
positive regulation of transporter activity
oxidative phosphorylation
positive regulation of calcium ion transport
positive regulation of cation transmembrane transport
regulation of calcium ion transmembrane transport
positive regulation of ion transmembrane transport
mitochondrial outer membrane
regulation of cation channel activity
positive regulation of transmembrane transport
ATP metabolic process
regulation of calcium ion transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
positive regulation of ion transport
regulation of transporter activity
regulation of cation transmembrane transport
regulation of metal ion transport
generation of precursor metabolites and energy
mitochondrion organization
regulation of ion transmembrane transport
regulation of transmembrane transport
regulation of ion transport
positive regulation of transport
mitochondrion
phosphorylation
positive regulation of molecular function
regulation of transport