GCM1

Entrez Summary: N/A
UniProt Summary: Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta- specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

astrocyte fate commitment
regulation of cell differentiation involved in embryonic placenta development
branching involved in labyrinthine layer morphogenesis
glial cell fate commitment
labyrinthine layer morphogenesis
embryonic placenta morphogenesis
cell differentiation involved in embryonic placenta development
positive regulation of syncytium formation by plasma membrane fusion
regulation of syncytium formation by plasma membrane fusion
labyrinthine layer development
astrocyte differentiation
embryonic placenta development
histone deacetylase binding
regulation of embryonic development
placenta development
morphogenesis of a branching epithelium
regulation of reproductive process
morphogenesis of a branching structure
glial cell differentiation
transcription factor complex
gliogenesis
cell fate commitment
transcription factor binding
in utero embryonic development
reproductive structure development
reproductive system development
morphogenesis of an epithelium
embryonic organ development
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
tissue morphogenesis
embryonic morphogenesis
chordate embryonic development
transcription, DNA-templated
nucleic acid-templated transcription
embryo development ending in birth or egg hatching
RNA biosynthetic process
developmental process involved in reproduction
DNA-binding transcription factor activity