GHSR
Gene Information
- Official Symbol: GHSR
- Official Name: growth hormone secretagogue receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 2693
- UniProt: Q92847
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010].
- UniProt Summary: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). {ECO:0000269|PubMed:10604470, ECO:0000269|PubMed:11322507}.
Pfam Domains GO Terms
Pfam Domains
| 7TM GPCR Srw |
| 7TM GPCR Srsx |
| 7TM GPCR Srv |
| 7tm 1 |
GO Terms
| ghrelin secretion |
| growth hormone secretagogue receptor activity |
| regulation of hindgut contraction |
| response to monosodium glutamate |
| regulation of small intestinal transit |
| positive regulation of small intestinal transit |
| negative regulation of locomotion involved in locomotory behavior |
| growth hormone-releasing hormone receptor activity |
| regulation of small intestine smooth muscle contraction |
| positive regulation of small intestine smooth muscle contraction |
| positive regulation of appetite |
| positive regulation of response to food |
| positive regulation of eating behavior |
| negative regulation of interleukin-6 biosynthetic process |
| integral component of synaptic membrane |
| regulation of gastric motility |
| regulation of gastro-intestinal system smooth muscle contraction |
| positive regulation of response to nutrient levels |
| positive regulation of response to extracellular stimulus |
| negative regulation of macrophage apoptotic process |
| positive regulation of gastro-intestinal system smooth muscle contraction |
| regulation of locomotion involved in locomotory behavior |
| growth hormone secretion |
| negative regulation of tumor necrosis factor biosynthetic process |
| regulation of eating behavior |
| negative regulation of norepinephrine secretion |
| regulation of neurotransmitter receptor localization to postsynaptic specialization membrane |
| cellular response to insulin-like growth factor stimulus |
| negative regulation of tumor necrosis factor secretion |
| positive regulation of feeding behavior |
| regulation of macrophage apoptotic process |
| positive regulation of digestive system process |
| adult feeding behavior |
| positive regulation of insulin-like growth factor receptor signaling pathway |
| negative regulation of response to food |
| negative regulation of appetite |
| regulation of growth hormone secretion |
| negative regulation of response to extracellular stimulus |
| negative regulation of response to nutrient levels |
| positive regulation of vascular endothelial cell proliferation |
| negative regulation of catecholamine secretion |
| postsynaptic modulation of chemical synaptic transmission |
| response to follicle-stimulating hormone |
| negative regulation of myeloid cell apoptotic process |
| regulation of norepinephrine secretion |
| cellular response to thyroid hormone stimulus |
| regulation of receptor localization to synapse |
| regulation of transmission of nerve impulse |
| negative regulation of behavior |
| response to salt |
| regulation of vascular endothelial cell proliferation |
| regulation of response to food |
| response to food |
| regulation of insulin-like growth factor receptor signaling pathway |
| regulation of interleukin-6 biosynthetic process |
| regulation of appetite |
| decidualization |
| regulation of response to extracellular stimulus |
| negative regulation of amine transport |
| regulation of response to nutrient levels |
| regulation of protein localization to synapse |
| response to thyroid hormone |
| negative regulation of interleukin-1 beta production |
| regulation of feeding behavior |
| positive regulation of behavior |
| response to gonadotropin |
| regulation of myeloid cell apoptotic process |
| regulation of tumor necrosis factor secretion |
| regulation of tumor necrosis factor biosynthetic process |
| negative regulation of cytokine biosynthetic process |
| positive regulation of smooth muscle contraction |
| positive regulation of multicellular organism growth |
| negative regulation of interleukin-1 production |
| positive regulation of fatty acid metabolic process |
| response to growth hormone |
| maternal placenta development |
| negative regulation of insulin secretion |
| positive regulation of sprouting angiogenesis |
| peptide hormone binding |
| response to dexamethasone |
| regulation of digestive system process |
| negative regulation of interleukin-6 production |
| negative regulation of peptide hormone secretion |
| positive regulation of muscle contraction |
| negative regulation of leukocyte apoptotic process |
| actin polymerization or depolymerization |
| peptide hormone secretion |
| negative regulation of tumor necrosis factor production |
| regulation of smooth muscle contraction |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| regulation of catecholamine secretion |
| negative regulation of hormone secretion |
| maternal process involved in female pregnancy |
| regulation of multicellular organism growth |
| negative regulation of cytokine secretion |
| regulation of sprouting angiogenesis |
| regulation of behavior |
| hormone secretion |
| regulation of interleukin-1 beta production |
| hormone transport |
| regulation of leukocyte apoptotic process |
| Schaffer collateral - CA1 synapse |
| postsynapse |
| feeding behavior |
| regulation of fatty acid metabolic process |
| regulation of amine transport |
| positive regulation of endothelial cell proliferation |
| response to antineoplastic agent |
| regulation of interleukin-1 production |
| regulation of postsynapse organization |
| regulation of synapse assembly |
| regulation of cytokine biosynthetic process |
| regulation of protein localization to cell periphery |
| regulation of endothelial cell proliferation |
| negative regulation of protein secretion |
| response to estradiol |
| regulation of nervous system process |
| negative regulation of inflammatory response |
| positive regulation of small molecule metabolic process |
| negative regulation of peptide secretion |
| regulation of interleukin-6 production |
| positive regulation of lipid metabolic process |
| adult behavior |
| response to glucocorticoid |
| drug transport |
| regulation of tumor necrosis factor production |
| regulation of tumor necrosis factor superfamily cytokine production |
| placenta development |
| regulation of muscle contraction |
| response to corticosteroid |
| cellular response to insulin stimulus |
| positive regulation of angiogenesis |
| signal release |
| hormone-mediated signaling pathway |
| positive regulation of developmental growth |
| regulation of cellular ketone metabolic process |
| peptide secretion |
| regulation of insulin secretion |
| female pregnancy |
| negative regulation of protein transport |
| positive regulation of vasculature development |
| cellular response to lipopolysaccharide |
| negative regulation of establishment of protein localization |
| positive regulation of epithelial cell proliferation |
| regulation of protein localization to membrane |
| cellular response to molecule of bacterial origin |
| response to ketone |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| negative regulation of defense response |
| regulation of peptide hormone secretion |
| multi-multicellular organism process |
| cellular response to biotic stimulus |
| regulation of synapse organization |
| membrane raft |
| regulation of synapse structure or activity |
| response to insulin |
| negative regulation of secretion |
| regulation of muscle system process |
| actin filament organization |
| positive regulation of growth |
| learning or memory |
| cellular response to peptide hormone stimulus |
| regulation of hormone secretion |
| negative regulation of cytokine production |
| regulation of angiogenesis |
| cognition |
| response to xenobiotic stimulus |
| response to lipopolysaccharide |
| neuron projection |
| regulation of vasculature development |
| negative regulation of locomotion |
| cellular response to peptide |
| response to molecule of bacterial origin |
| response to steroid hormone |
| regulation of developmental growth |
| regulation of epithelial cell proliferation |
| regulation of inflammatory response |
| glutamatergic synapse |
| negative regulation of response to external stimulus |
| response to peptide hormone |
| regulation of lipid metabolic process |
| reproductive structure development |
| regulation of small molecule metabolic process |
| reproductive system development |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| supramolecular fiber organization |
| regulation of protein secretion |
| response to peptide |
| negative regulation of transport |
| actin cytoskeleton organization |
| regulation of peptide secretion |
| response to nutrient levels |
| cellular response to lipid |
| response to extracellular stimulus |
| regulation of hormone levels |
| regulation of cellular protein localization |
| spermatogenesis |
| male gamete generation |
| actin filament-based process |
| behavior |
| regulation of system process |
| cellular response to organonitrogen compound |
| positive regulation of response to external stimulus |
| cellular response to hormone stimulus |
| cell surface |
| cellular response to nitrogen compound |
| developmental process involved in reproduction |
| regulation of growth |
| response to bacterium |
| gamete generation |
| regulation of cytokine production |
| regulation of protein transport |
| G protein-coupled receptor activity |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| regulation of secretion |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| response to lipid |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cellular component biogenesis |
| regulation of locomotion |
| negative regulation of cell death |
| multi-organism reproductive process |
| response to organonitrogen compound |
| secretion by cell |
| response to drug |
| regulation of protein localization |
| export from cell |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| cell-cell signaling |
| secretion |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| response to other organism |
| response to external biotic stimulus |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| reproductive process |
| reproduction |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| peptide transport |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| amide transport |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of cell communication |
| positive regulation of signaling |
| nitrogen compound transport |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Etoposide 10μM R00 exp20 | -1.8 |
| Epothilone-B 0.0015μM R05 exp231 | -1.7 |
| 3-Bromopyruvate 7μM R04 exp175 | 1.82 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16783
- Expression level (log2 read counts): -7.68
Expression Distribution
GHSR Expression in NALM6 Cells: -7.68
