GLIS2

Gene Information

Official Symbol: GLIS2
Official Name: GLIS family zinc finger 2
Aliases and Previous Symbols: N/A
Entrez ID: 84662
UniProt: Q9BZE0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010].
UniProt Summary: Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6284
Expression level (log2 read counts): 1.27

Expression Distribution

Screen	Score
Mubritinib 0.2μM R02 exp65	-1.95
A-395 10μM R05 exp218	-1.79
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.72
Myriocin 25μM R06 exp293	1.81

regulation of transcription from RNA polymerase II promoter involved in kidney development
negative regulation of smoothened signaling pathway
non-motile cilium
cell differentiation involved in kidney development
positive regulation of protein localization to nucleus
regulation of smoothened signaling pathway
regulation of protein localization to nucleus
negative regulation of DNA-binding transcription factor activity
transcription regulatory region DNA binding
kidney development
renal system development
RNA polymerase II regulatory region sequence-specific DNA binding
urogenital system development
positive regulation of cellular protein localization
nuclear speck
regulation of DNA-binding transcription factor activity
DNA-binding transcription activator activity, RNA polymerase II-specific
regulation of cellular protein localization
negative regulation of transcription by RNA polymerase II
regulation of cellular localization
central nervous system development
regulation of protein localization
negative regulation of molecular function
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of signal transduction
negative regulation of RNA metabolic process
negative regulation of cell communication
negative regulation of signaling
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of response to stimulus
positive regulation of nucleic acid-templated transcription