GOLPH3

Entrez Summary: N/A
UniProt Summary: Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763, ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Q15 2.7μM R02 exp79	-1.82
Monensin 0.3μM R08 exp507	-1.76
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.88
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.01
Ibrutinib 1μM R07 exp372	2.09

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

asymmetric Golgi ribbon formation
cell adhesion molecule production
protein retention in Golgi apparatus
Golgi cisterna
Golgi ribbon formation
leukocyte tethering or rolling
leukocyte adhesion to vascular endothelial cell
protein localization to Golgi apparatus
phosphatidylinositol-4-phosphate binding
establishment of epithelial cell polarity
lamellipodium assembly
Golgi to plasma membrane protein transport
positive regulation of TOR signaling
cellular extravasation
lamellipodium organization
leukocyte cell-cell adhesion
establishment of protein localization to plasma membrane
Golgi to plasma membrane transport
maintenance of protein location in cell
mitochondrial intermembrane space
Golgi vesicle budding
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Golgi cisterna membrane
vesicle-mediated transport to the plasma membrane
maintenance of location in cell
vesicle budding from membrane
post-Golgi vesicle-mediated transport
regulation of TOR signaling
maintenance of protein location
establishment of cell polarity
Golgi organization
protein secretion
establishment of protein localization to extracellular region
maintenance of location
protein localization to extracellular region
trans-Golgi network
peptide secretion
regulation of mitochondrion organization
protein localization to plasma membrane
establishment or maintenance of cell polarity