GPR27

Gene Information

Official Symbol: GPR27
Official Name: G protein-coupled receptor 27
Aliases and Previous Symbols: N/A
Entrez ID: 2850
UniProt: Q9NS67
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Orphan receptor. Possible candidate for amine-like G- protein coupled receptor.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6290
Expression level (log2 read counts): -3.42

Expression Distribution

Screen	Score
THZ531 0.11μM R07 exp409	-1.83
Thioridazine 5μM R08 exp530	1.78
Ethanol 0.01 R05 exp234	1.85

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
positive regulation of G protein-coupled receptor signaling pathway
positive regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of insulin secretion
positive regulation of peptide hormone secretion
positive regulation of hormone secretion
regulation of G protein-coupled receptor signaling pathway
regulation of insulin secretion
regulation of peptide hormone secretion
regulation of hormone secretion
positive regulation of protein secretion
positive regulation of peptide secretion
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of establishment of protein localization
regulation of protein secretion
regulation of peptide secretion
regulation of hormone levels
regulation of protein transport
G protein-coupled receptor activity
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of secretion
regulation of cellular localization
positive regulation of transport
regulation of protein localization
G protein-coupled receptor signaling pathway
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of transport