GRB7

Entrez Summary: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

stress granule assembly
ERBB2 signaling pathway
negative regulation of insulin receptor signaling pathway
negative regulation of cellular response to insulin stimulus
epidermal growth factor receptor signaling pathway
SH3/SH2 adaptor activity
regulation of insulin receptor signaling pathway
cytoplasmic stress granule
ERBB signaling pathway
regulation of cellular response to insulin stimulus
phosphatidylinositol binding
insulin receptor signaling pathway
cell projection
negative regulation of translation
negative regulation of cellular amide metabolic process
cellular response to insulin stimulus
response to insulin
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
axon guidance
neuron projection guidance
cellular response to peptide hormone stimulus
cellular response to peptide
regulation of translation
axonogenesis
leukocyte migration
response to peptide hormone
regulation of cellular amide metabolic process
axon development
focal adhesion
cell morphogenesis involved in neuron differentiation
ribonucleoprotein complex biogenesis
protein kinase binding
response to peptide
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
positive regulation of cell migration
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis