GSPT1

Entrez Summary: N/A
UniProt Summary: Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 686/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	26/28
bone	23/26
breast	32/33
central nervous system	53/56
cervix	4/4
colorectal	17/17
esophagus	12/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	18/20
lung	69/75
lymphocyte	15/16
ovary	25/26
pancreas	23/24
peripheral nervous system	14/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	28/29
uterus	5/5

Expression Distribution

cytoplasmic translational termination
translation release factor complex
translation release factor activity
cytoplasmic translation
translational termination
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
protein alkylation
protein methylation
cellular protein complex disassembly
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
protein-containing complex disassembly
RNA catabolic process
macromolecule methylation
mitotic cell cycle phase transition
cell cycle phase transition
methylation
GTPase activity
nucleobase-containing compound catabolic process
translation
GTP binding
cellular component disassembly
peptide biosynthetic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
amide biosynthetic process
peptide metabolic process
mitotic cell cycle process
mitotic cell cycle
mRNA metabolic process
cellular amide metabolic process
cellular macromolecule catabolic process
cell cycle process
macromolecule catabolic process
cell cycle
RNA binding