GUCA2A

Entrez Summary: N/A
UniProt Summary: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

guanylate cyclase activator activity
positive regulation of guanylate cyclase activity
regulation of guanylate cyclase activity
positive regulation of nucleotide biosynthetic process
positive regulation of cyclase activity
positive regulation of purine nucleotide biosynthetic process
positive regulation of lyase activity
regulation of purine nucleotide biosynthetic process
regulation of nucleotide biosynthetic process
regulation of cyclase activity
regulation of lyase activity
positive regulation of nucleotide metabolic process
positive regulation of purine nucleotide metabolic process
hormone activity
digestion
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
positive regulation of small molecule metabolic process
regulation of small molecule metabolic process
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of catalytic activity
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of nucleobase-containing compound metabolic process
extracellular region
positive regulation of cellular biosynthetic process
positive regulation of biosynthetic process