GUCA2B

Gene Information

Official Symbol: GUCA2B
Official Name: guanylate cyclase activator 2B
Aliases and Previous Symbols: N/A
Entrez ID: 2981
UniProt: Q16661
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-2.29
Chloramphenicol 2μM R00 exp12	-1.98
NFN1 1μM R03 exp100	-1.82
Resveratrol 16μM R03 exp147	-1.77
Bortezomib 0.005μM R00 exp6	-1.75
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.71

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8032
Expression level (log2 read counts): -1.85

Expression Distribution

guanylate cyclase activator activity
calcium sensitive guanylate cyclase activator activity
positive regulation of guanylate cyclase activity
regulation of guanylate cyclase activity
positive regulation of cyclase activity
positive regulation of purine nucleotide biosynthetic process
positive regulation of nucleotide biosynthetic process
positive regulation of lyase activity
cGMP-mediated signaling
regulation of purine nucleotide biosynthetic process
regulation of nucleotide biosynthetic process
excretion
regulation of cyclase activity
positive regulation of purine nucleotide metabolic process
positive regulation of nucleotide metabolic process
negative regulation of blood pressure
regulation of lyase activity
photoreceptor outer segment
body fluid secretion
digestion
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
positive regulation of small molecule metabolic process
cyclic-nucleotide-mediated signaling
regulation of blood pressure
second-messenger-mediated signaling
blood circulation
circulatory system process
regulation of small molecule metabolic process
regulation of body fluid levels
secretion
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of catalytic activity
intracellular signal transduction
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of nucleobase-containing compound metabolic process
extracellular region