GUSB

Entrez Summary: This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014].
UniProt Summary: Plays an important role in the degradation of dermatan and keratan sulfates.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Actinomycin-D 0.01μM R00 exp4	-3.07
Ribavirin 10μM R01 exp52	2.04

glucuronoside catabolic process
glucuronoside metabolic process
beta-glucuronidase activity
glycoside catabolic process
hyaluronan catabolic process
glycoside metabolic process
hyaluronan metabolic process
cellular carbohydrate catabolic process
glycosyl compound catabolic process
glycosaminoglycan catabolic process
aminoglycan catabolic process
azurophil granule lumen
lysosomal lumen
mucopolysaccharide metabolic process
carbohydrate catabolic process
ficolin-1-rich granule lumen
glycosyl compound metabolic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
cellular carbohydrate metabolic process
carbohydrate binding
carbohydrate derivative catabolic process
protein domain specific binding
organic acid catabolic process
carboxylic acid catabolic process
signaling receptor binding
small molecule catabolic process
carbohydrate metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
intracellular membrane-bounded organelle