GZF1
Gene Information
- Official Symbol: GZF1
- Official Name: GDNF inducible zinc finger protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 64412
- UniProt: Q9H116
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| BTB |
GO Terms
| branching involved in ureteric bud morphogenesis |
| ureteric bud morphogenesis |
| mesonephric tubule morphogenesis |
| nephron tubule morphogenesis |
| nephron epithelium morphogenesis |
| nephron morphogenesis |
| renal tubule morphogenesis |
| nephron tubule development |
| renal tubule development |
| kidney morphogenesis |
| ureteric bud development |
| mesonephric epithelium development |
| mesonephric tubule development |
| mesonephros development |
| nephron epithelium development |
| RNA polymerase II distal enhancer sequence-specific DNA binding |
| nephron development |
| kidney epithelium development |
| branching morphogenesis of an epithelial tube |
| morphogenesis of a branching epithelium |
| morphogenesis of a branching structure |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| kidney development |
| renal system development |
| epithelial tube morphogenesis |
| urogenital system development |
| sequence-specific DNA binding |
| morphogenesis of an epithelium |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| tissue morphogenesis |
| tube morphogenesis |
| tube development |
| nucleolus |
| negative regulation of transcription by RNA polymerase II |
| animal organ morphogenesis |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| negative regulation of gene expression |
| tissue development |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rotenone 2μM R00 exp33 | -2.43 |
| Latrunculin-B 10μM R07 exp374 | -2.17 |
| HMS-I2 10μM R06 exp288 | 1.73 |
| ZLN024 50μM R08 exp538 | 1.77 |
| Talazoparib 0.006μM R06 exp299 | 1.84 |
| Citral 50μM R06 exp274 | 1.88 |
| BI-2536 0.0042μM R03 exp95 | 1.9 |
| Demecolcine 0.03μM R05 exp228 | 1.92 |
| Sucrose 20000μM R06 exp298 | 1.98 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.455 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4417
- Expression level (log2 read counts): 4.87
Expression Distribution
GZF1 Expression in NALM6 Cells: 4.87