GZMB

Gene Information

Official Symbol: GZMB
Official Name: granzyme B
Aliases and Previous Symbols: N/A
Entrez ID: 3002
UniProt: P10144
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016].
UniProt Summary: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 0.1μM R01 exp49	1.72
HMS-I1 10μM R06 exp256	1.74
Nifuroxazide 1μM R01 exp51	1.92
Isoniazid 100μM R08 exp494	1.93
Docetaxel 0.002μM R01 exp45	2.15

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4011
Expression level (log2 read counts): -6.6

Expression Distribution

Gene	Correlation
RRM1	0.583
RUVBL2	0.422

granzyme-mediated apoptotic signaling pathway
cytolysis
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
natural killer cell mediated cytotoxicity
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
natural killer cell mediated immunity
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
immunological synapse
leukocyte mediated cytotoxicity
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of establishment of protein localization to mitochondrion
serine-type peptidase activity
regulation of mitochondrial membrane permeability
regulation of establishment of protein localization to mitochondrion
regulation of membrane permeability
cell killing
positive regulation of mitochondrion organization
positive regulation of protein localization to membrane
mitochondrial membrane organization
serine-type endopeptidase activity
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
regulation of protein localization to membrane
mitochondrial transport
lymphocyte mediated immunity
apoptotic signaling pathway
positive regulation of cellular protein localization
regulation of apoptotic signaling pathway
mitochondrion organization
positive regulation of establishment of protein localization
regulation of cellular protein localization
positive regulation of organelle organization
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of establishment of protein localization
leukocyte mediated immunity
innate immune response
membrane organization
regulation of cellular localization